Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability

OBJECTIVE: As diabetes develops, marked reductions of insulin secretion are associated with very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell differentiation enough to account for the altered function. METHODS: Rats were subjected to 90% partial pancreatectomi...

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Detalles Bibliográficos
Autores principales: Ebrahimi, Aref G., Hollister-Lock, Jennifer, Sullivan, Brooke A., Tsuchida, Ryohei, Bonner-Weir, Susan, Weir, Gordon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082551/
https://www.ncbi.nlm.nih.gov/pubmed/32244186
http://dx.doi.org/10.1016/j.molmet.2020.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082551/
https://www.ncbi.nlm.nih.gov/pubmed/32244186
http://dx.doi.org/10.1016/j.molmet.2020.02.002

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