Cargando…

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity

OBJECTIVE: The steep rise in the prevalence of obesity and its related metabolic syndrome have become a major worldwide health concerns. Melanocortin peptides from hypothalamic arcuate nucleus (Arc) POMC neurons induce satiety to limit food intake. Consequently, Arc Pomc-deficient mice (ArcPomc(−/−)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Hui, Chhabra, Kavaljit H., Thompson, Zoe, Jones, Graham L., Kiran, Sylee, Shangguan, Gary, Low, Malcolm J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082555/ https://www.ncbi.nlm.nih.gov/pubmed/32244188 http://dx.doi.org/10.1016/j.molmet.2020.01.021

Ejemplares similares

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
por: Tooke, Benjamin P., et al.
Publicado: (2018)

SAT-299 Chronic Treatment Of Juvenile Hypothalamic Pomc-deficient Mice With RM-493 Prevents The Development Of Obesity
por: Thompson, Zoe, et al.
Publicado: (2020)

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
por: Jones, Graham L., et al.
Publicado: (2019)

OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background
por: Gahlot, Surbhi, et al.
Publicado: (2020)

Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice
por: Chhabra, Kavaljit H., et al.
Publicado: (2017)

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity
por: Kim, Geun Hyang, et al.
Publicado: (2018)

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons
por: Hu, Jun, et al.
Publicado: (2014)

MON-709 Single-Cell RNA-Sequencing Deciphers POMC Neuron Destiny
por: Yu, Hui, et al.
Publicado: (2020)

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes
por: Yu, Hui, et al.
Publicado: (2022)

Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity
por: Souza, Gabriela F. P., et al.
Publicado: (2016)

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
por: Burke, Luke K., et al.
Publicado: (2016)

Lactate activates hypothalamic POMC neurons by intercellular signaling
por: Órdenes, P., et al.
Publicado: (2021)

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
por: Sun, Jia, et al.
Publicado: (2016)

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity
por: Gamber, Kevin M., et al.
Publicado: (2012)

Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity
por: McFadden, Taylor, et al.
Publicado: (2023)

Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons
por: Hill, Jennifer W.
Publicado: (2010)

Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2
por: Zanesco, Ariane Maria, et al.
Publicado: (2022)

Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats
por: Zhou, Shengnan, et al.
Publicado: (2022)

Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Obesity, POMC, and POMC-processing Enzymes: Surprising Results From Animal Models
por: Lindberg, Iris, et al.
Publicado: (2021)

Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity
por: Ibars, M, et al.
Publicado: (2017)

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice
por: Trotta, Milagros, et al.
Publicado: (2020)

Magel2 knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity
por: Choi, Yuna, et al.
Publicado: (2022)

Correction: Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Pomc-expressing progenitors give rise to antagonistic populations in hypothalamic feeding circuits
por: Padilla, Stephanie L., et al.
Publicado: (2010)

Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3′UTR
por: Derghal, Adel, et al.
Publicado: (2015)

Olanzapine- induced metabolic syndrome pathogenesis: Hypothalamic “leptin resistance” or “pomc resistance”?
por: Veneziani, F., et al.
Publicado: (2021)

5-HT Obesity Medication Efficacy via POMC Activation is Maintained During Aging
por: Burke, Luke K., et al.
Publicado: (2014)

InsR/FoxO1 Signaling Curtails Hypothalamic POMC Neuron Number
por: Plum, Leona, et al.
Publicado: (2012)

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring
por: Silva, Jose P., et al.
Publicado: (2016)

Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats
por: Gali Ramamoorthy, Thanuja, et al.
Publicado: (2018)

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
por: Varela, Luis, et al.
Publicado: (2017)

Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake
por: Ha, Go Eun, et al.
Publicado: (2021)

Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide
por: Wabitsch, Martin, et al.
Publicado: (2022)

ODP607 Long-term Efficacy of Setmelanotide in Patients With POMC or LEPR Deficiency Obesity
por: Clément, Karine, et al.
Publicado: (2022)

Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding
por: Suyama, Shigetomo, et al.
Publicado: (2016)

Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice
por: Mercer, Rebecca E., et al.
Publicado: (2013)

Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression
por: Lage, Ricardo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_30vdjk8jhg72jej9pd2vodnrdq