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Assessing the effect of genetic markers on drug immunogenicity from a mechanistic model-based approach
BACKGROUND: With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-existing antibodies or to the novel production of antibodies from B-cell clones...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082907/ https://www.ncbi.nlm.nih.gov/pubmed/32192445 http://dx.doi.org/10.1186/s12874-020-00941-z |