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Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era

Hardy-Weinberg Equilibrium (HWE) is used to estimate the number of homozygous and heterozygous variant carriers based on its allele frequency in populations that are not evolving. Deviations from HWE in large population databases have been used to detect genotyping errors, which can result in extrem...

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Detalles Bibliográficos
Autores principales: Abramovs, Nikita, Brass, Andrew, Tassabehji, May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083100/
https://www.ncbi.nlm.nih.gov/pubmed/32231685
http://dx.doi.org/10.3389/fgene.2020.00210