In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP enzymes. Incubation of [(14)C]‐ataluren with hum...

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Detalles Bibliográficos
Autores principales: Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Moon, Young‐Choon, Welch, Ellen M., Weetall, Marla, Colacino, Joseph M., Almstead, Neil, Babiak, John, Goodwin, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083565/
https://www.ncbi.nlm.nih.gov/pubmed/32196986
http://dx.doi.org/10.1002/prp2.576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083565/
https://www.ncbi.nlm.nih.gov/pubmed/32196986
http://dx.doi.org/10.1002/prp2.576

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