The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

The serotonin transporter (SERT) terminates serotonin signaling by rapid presynaptic reuptake. SERT activity is modulated by antidepressants, e.g., S-citalopram and imipramine, to alleviate symptoms of depression and anxiety. SERT crystal structures reveal two S-citalopram binding pockets in the cen...

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Detalles Bibliográficos
Autores principales: Plenge, Per, Abramyan, Ara M., Sørensen, Gunnar, Mørk, Arne, Weikop, Pia, Gether, Ulrik, Bang-Andersen, Benny, Shi, Lei, Loland, Claus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083837/
https://www.ncbi.nlm.nih.gov/pubmed/32198394
http://dx.doi.org/10.1038/s41467-020-15292-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083837/
https://www.ncbi.nlm.nih.gov/pubmed/32198394
http://dx.doi.org/10.1038/s41467-020-15292-y

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