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The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

The serotonin transporter (SERT) terminates serotonin signaling by rapid presynaptic reuptake. SERT activity is modulated by antidepressants, e.g., S-citalopram and imipramine, to alleviate symptoms of depression and anxiety. SERT crystal structures reveal two S-citalopram binding pockets in the cen...

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Detalles Bibliográficos
Autores principales:	Plenge, Per, Abramyan, Ara M., Sørensen, Gunnar, Mørk, Arne, Weikop, Pia, Gether, Ulrik, Bang-Andersen, Benny, Shi, Lei, Loland, Claus J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083837/ https://www.ncbi.nlm.nih.gov/pubmed/32198394 http://dx.doi.org/10.1038/s41467-020-15292-y

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