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Loss of copy of MIR1-2 increases CDK4 expression in ileal neuroendocrine tumors

Ileal neuroendocrine tumors (I-NETs) are the most common tumors of the small intestine. Although I-NETs are known for a lack of recurrently mutated genes, a majority of tumors do show loss of one copy of chromosome 18. Among the genes on chromosome 18 is MIR1-2, which encodes a microRNA, MIR1-3p, wi...

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Detalles Bibliográficos
Autores principales: Contractor, Tanupriya, Harris, Chris R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083839/
https://www.ncbi.nlm.nih.gov/pubmed/32198354
http://dx.doi.org/10.1038/s41389-020-0221-4