Insulin activates hepatic Wnt/β-catenin signaling through stearoyl-CoA desaturase 1 and Porcupine

The Wnt/β-catenin pathway plays a pivotal role in liver structural and metabolic homeostasis. Wnt activity is tightly regulated by the acyltransferase Porcupine through the addition of palmitoleate. Interestingly palmitoleate can be endogenously produced by the stearoyl-CoA desaturase 1 (SCD1), a li...

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Detalles Bibliográficos
Autores principales: Cabrae, Régine, Dubuquoy, Céline, Caüzac, Michèle, Morzyglod, Lucille, Guilmeau, Sandra, Noblet, Bénédicte, Fève, Bruno, Postic, Catherine, Burnol, Anne-Françoise, Moldes, Marthe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083857/
https://www.ncbi.nlm.nih.gov/pubmed/32198362
http://dx.doi.org/10.1038/s41598-020-61869-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083857/
https://www.ncbi.nlm.nih.gov/pubmed/32198362
http://dx.doi.org/10.1038/s41598-020-61869-4

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