Degree and site of chromosomal instability define its oncogenic potential

Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still unclear. Using a conditional mouse model for divers...

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Detalles Bibliográficos
Autores principales: Hoevenaar, Wilma H. M., Janssen, Aniek, Quirindongo, Ajit I., Ma, Huiying, Klaasen, Sjoerd J., Teixeira, Antoinette, van Gerwen, Bastiaan, Lansu, Nico, Morsink, Folkert H. M., Offerhaus, G. Johan A., Medema, René H., Kops, Geert J. P. L., Jelluma, Nannette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083897/
https://www.ncbi.nlm.nih.gov/pubmed/32198375
http://dx.doi.org/10.1038/s41467-020-15279-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083897/
https://www.ncbi.nlm.nih.gov/pubmed/32198375
http://dx.doi.org/10.1038/s41467-020-15279-9

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