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Epistatic contributions promote the unification of incompatible models of neutral molecular evolution

We introduce a model of amino acid sequence evolution that accounts for the statistical behavior of real sequences induced by epistatic interactions. We base the model dynamics on parameters derived from multiple sequence alignments analyzed by using direct coupling analysis methodology. Known stati...

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Detalles Bibliográficos
Autores principales: de la Paz, Jose Alberto, Nartey, Charisse M., Yuvaraj, Monisha, Morcos, Faruck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084075/
https://www.ncbi.nlm.nih.gov/pubmed/32123092
http://dx.doi.org/10.1073/pnas.1913071117