TDP-43 α-helical structure tunes liquid–liquid phase separation and function

Liquid–liquid phase separation (LLPS) is involved in the formation of membraneless organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is present in several MLOs, undergoes LLPS, and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). While some A...

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Detalles Bibliográficos
Autores principales: Conicella, Alexander E., Dignon, Gregory L., Zerze, Gül H., Schmidt, Hermann Broder, D’Ordine, Alexandra M., Kim, Young C., Rohatgi, Rajat, Ayala, Yuna M., Mittal, Jeetain, Fawzi, Nicolas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084079/
https://www.ncbi.nlm.nih.gov/pubmed/32132204
http://dx.doi.org/10.1073/pnas.1912055117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084079/
https://www.ncbi.nlm.nih.gov/pubmed/32132204
http://dx.doi.org/10.1073/pnas.1912055117

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