Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

T helper (Th) cells are CD4(+) effector T cells that play a critical role in immunity by shaping the inflammatory cytokine environment in a variety of physiological and pathological situations. Using a combined chemico-genetic approach, we identify histone H3K27 demethylases KDM6A and KDM6B as centr...

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Detalles Bibliográficos
Autores principales: Cribbs, Adam P., Terlecki-Zaniewicz, Stefan, Philpott, Martin, Baardman, Jeroen, Ahern, David, Lindow, Morten, Obad, Susanna, Oerum, Henrik, Sampey, Brante, Mander, Palwinder K., Penn, Henry, Wordsworth, Paul, Bowness, Paul, de Winther, Menno, Prinjha, Rab K., Feldmann, Marc, Oppermann, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084125/
https://www.ncbi.nlm.nih.gov/pubmed/32123118
http://dx.doi.org/10.1073/pnas.1919893117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084125/
https://www.ncbi.nlm.nih.gov/pubmed/32123118
http://dx.doi.org/10.1073/pnas.1919893117

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