The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment

Th17 cells represent a subset of CD4+ T cells characterized by the master transcription factor RORγt and the production of IL-17. Epigenetic modifications such as post-translational histone modifications and DNA methylation play a key role in Th17 cell differentiation and high plasticity. Th17 cells...

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Autores principales: Renaude, Elodie, Kroemer, Marie, Loyon, Romain, Binda, Delphine, Borg, Christophe, Guittaut, Michaël, Hervouet, Eric, Peixoto, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084267/
https://www.ncbi.nlm.nih.gov/pubmed/32121394
http://dx.doi.org/10.3390/ijms21051673
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author Renaude, Elodie
Kroemer, Marie
Loyon, Romain
Binda, Delphine
Borg, Christophe
Guittaut, Michaël
Hervouet, Eric
Peixoto, Paul
author_facet Renaude, Elodie
Kroemer, Marie
Loyon, Romain
Binda, Delphine
Borg, Christophe
Guittaut, Michaël
Hervouet, Eric
Peixoto, Paul
author_sort Renaude, Elodie
collection PubMed
description Th17 cells represent a subset of CD4+ T cells characterized by the master transcription factor RORγt and the production of IL-17. Epigenetic modifications such as post-translational histone modifications and DNA methylation play a key role in Th17 cell differentiation and high plasticity. Th17 cells are highly recruited in many types of cancer and can be associated with good or bad prognosis. Here, we will review the remodeling of the epigenome induced by the tumor microenvironment, which may explain Th17 cell predominance. We will also discuss the promising treatment perspectives of molecules targeting epigenetic enzymes to remodel a Th17-enriched tumor microenvironment.
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spelling pubmed-70842672020-03-24 The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment Renaude, Elodie Kroemer, Marie Loyon, Romain Binda, Delphine Borg, Christophe Guittaut, Michaël Hervouet, Eric Peixoto, Paul Int J Mol Sci Review Th17 cells represent a subset of CD4+ T cells characterized by the master transcription factor RORγt and the production of IL-17. Epigenetic modifications such as post-translational histone modifications and DNA methylation play a key role in Th17 cell differentiation and high plasticity. Th17 cells are highly recruited in many types of cancer and can be associated with good or bad prognosis. Here, we will review the remodeling of the epigenome induced by the tumor microenvironment, which may explain Th17 cell predominance. We will also discuss the promising treatment perspectives of molecules targeting epigenetic enzymes to remodel a Th17-enriched tumor microenvironment. MDPI 2020-02-29 /pmc/articles/PMC7084267/ /pubmed/32121394 http://dx.doi.org/10.3390/ijms21051673 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Renaude, Elodie
Kroemer, Marie
Loyon, Romain
Binda, Delphine
Borg, Christophe
Guittaut, Michaël
Hervouet, Eric
Peixoto, Paul
The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment
title The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment
title_full The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment
title_fullStr The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment
title_full_unstemmed The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment
title_short The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment
title_sort fate of th17 cells is shaped by epigenetic modifications and remodeled by the tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084267/
https://www.ncbi.nlm.nih.gov/pubmed/32121394
http://dx.doi.org/10.3390/ijms21051673
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