Differential Inhibitory Actions of Multitargeted Tyrosine Kinase Inhibitors on Different Ionic Current Types in Cardiomyocytes

Lapatinib (LAP) and sorafenib (SOR) are multitargeted tyrosine kinase inhibitors (TKIs) with antineoplastic properties. In clinical observations, LAP and SOR may contribute to QTc prolongation, but the detailed mechanism for this has been largely unexplored. In this study, we investigated whether LA...

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Detalles Bibliográficos
Autores principales: Chang, Wei-Ting, Liu, Ping-Yen, Lee, Kaisen, Feng, Yin-Hsun, Wu, Sheng-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084345/
https://www.ncbi.nlm.nih.gov/pubmed/32121388
http://dx.doi.org/10.3390/ijms21051672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084345/
https://www.ncbi.nlm.nih.gov/pubmed/32121388
http://dx.doi.org/10.3390/ijms21051672

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