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Contributions of DNA Damage to Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common type of neurodegenerative disease. Its typical pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles. Mutations in the APP, PSEN1, and PSEN2 genes increase Aβ production and aggregation, and thus cause ear...

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Autores principales: Lin, Xiaozeng, Kapoor, Anil, Gu, Yan, Chow, Mathilda Jing, Peng, Jingyi, Zhao, Kuncheng, Tang, Damu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084447/
https://www.ncbi.nlm.nih.gov/pubmed/32121304
http://dx.doi.org/10.3390/ijms21051666
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author Lin, Xiaozeng
Kapoor, Anil
Gu, Yan
Chow, Mathilda Jing
Peng, Jingyi
Zhao, Kuncheng
Tang, Damu
author_facet Lin, Xiaozeng
Kapoor, Anil
Gu, Yan
Chow, Mathilda Jing
Peng, Jingyi
Zhao, Kuncheng
Tang, Damu
author_sort Lin, Xiaozeng
collection PubMed
description Alzheimer’s disease (AD) is the most common type of neurodegenerative disease. Its typical pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles. Mutations in the APP, PSEN1, and PSEN2 genes increase Aβ production and aggregation, and thus cause early onset or familial AD. Even with this strong genetic evidence, recent studies support AD to result from complex etiological alterations. Among them, aging is the strongest risk factor for the vast majority of AD cases: Sporadic late onset AD (LOAD). Accumulation of DNA damage is a well-established aging factor. In this regard, a large amount of evidence reveals DNA damage as a critical pathological cause of AD. Clinically, DNA damage is accumulated in brains of AD patients. Genetically, defects in DNA damage repair resulted from mutations in the BRAC1 and other DNA damage repair genes occur in AD brain and facilitate the pathogenesis. Abnormalities in DNA damage repair can be used as diagnostic biomarkers for AD. In this review, we discuss the association, the causative potential, and the biomarker values of DNA damage in AD pathogenesis.
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spelling pubmed-70844472020-03-24 Contributions of DNA Damage to Alzheimer’s Disease Lin, Xiaozeng Kapoor, Anil Gu, Yan Chow, Mathilda Jing Peng, Jingyi Zhao, Kuncheng Tang, Damu Int J Mol Sci Review Alzheimer’s disease (AD) is the most common type of neurodegenerative disease. Its typical pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau neurofibrillary tangles. Mutations in the APP, PSEN1, and PSEN2 genes increase Aβ production and aggregation, and thus cause early onset or familial AD. Even with this strong genetic evidence, recent studies support AD to result from complex etiological alterations. Among them, aging is the strongest risk factor for the vast majority of AD cases: Sporadic late onset AD (LOAD). Accumulation of DNA damage is a well-established aging factor. In this regard, a large amount of evidence reveals DNA damage as a critical pathological cause of AD. Clinically, DNA damage is accumulated in brains of AD patients. Genetically, defects in DNA damage repair resulted from mutations in the BRAC1 and other DNA damage repair genes occur in AD brain and facilitate the pathogenesis. Abnormalities in DNA damage repair can be used as diagnostic biomarkers for AD. In this review, we discuss the association, the causative potential, and the biomarker values of DNA damage in AD pathogenesis. MDPI 2020-02-28 /pmc/articles/PMC7084447/ /pubmed/32121304 http://dx.doi.org/10.3390/ijms21051666 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Xiaozeng
Kapoor, Anil
Gu, Yan
Chow, Mathilda Jing
Peng, Jingyi
Zhao, Kuncheng
Tang, Damu
Contributions of DNA Damage to Alzheimer’s Disease
title Contributions of DNA Damage to Alzheimer’s Disease
title_full Contributions of DNA Damage to Alzheimer’s Disease
title_fullStr Contributions of DNA Damage to Alzheimer’s Disease
title_full_unstemmed Contributions of DNA Damage to Alzheimer’s Disease
title_short Contributions of DNA Damage to Alzheimer’s Disease
title_sort contributions of dna damage to alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084447/
https://www.ncbi.nlm.nih.gov/pubmed/32121304
http://dx.doi.org/10.3390/ijms21051666
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