A Capped Peptide of the Aggregation Prone NAC 71–82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations

Although Lewy bodies and Lewy neurites are hallmarks of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), misfolded α-synuclein oligomers are nowadays believed to be key for the development of these diseases. Attempts to target soluble misfolded species of the full-length protein have be...

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Detalles Bibliográficos
Autores principales: Näsström, Thomas, Ådén, Jörgen, Shibata, Fumina, Andersson, Per Ola, Karlsson, Björn C.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084662/
https://www.ncbi.nlm.nih.gov/pubmed/32120928
http://dx.doi.org/10.3390/ijms21051629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084662/
https://www.ncbi.nlm.nih.gov/pubmed/32120928
http://dx.doi.org/10.3390/ijms21051629

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