Conformational Insight on WT- and Mutated-EGFR Receptor Activation and Inhibition by Epigallocatechin-3-Gallate: Over a Rational Basis for the Design of Selective Non-Small-Cell Lung Anticancer Agents

Non-small cell lung cancer (NSCLC) represents a difficult condition to treat, due to epidermal growth factor receptor (EGFR) kinase domain mutations, which lead to ligand-independent phosphorylation. Deletion of five amino acids (ELREA) in exon 19 and mutational change from leucine to arginine at po...

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Detalles Bibliográficos
Autores principales: Minnelli, Cristina, Laudadio, Emiliano, Mobbili, Giovanna, Galeazzi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084708/
https://www.ncbi.nlm.nih.gov/pubmed/32138321
http://dx.doi.org/10.3390/ijms21051721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084708/
https://www.ncbi.nlm.nih.gov/pubmed/32138321
http://dx.doi.org/10.3390/ijms21051721

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