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In Silico Insights into Protein–Protein Interaction Disruptive Mutations in the PCSK9-LDLR Complex
Gain-of-function mutations in PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to reduced uptake of LDL (low density lipoprotein) cholesterol and, therefore, increased plasma LDL levels. However, the mechanism by which these mutants reduce LDL reuptake is not fully understood. Here, we hav...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084799/ https://www.ncbi.nlm.nih.gov/pubmed/32106405 http://dx.doi.org/10.3390/ijms21051550 |