Cargando…

Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells

Leucine-rich repeat kinase 2 (LRRK2) is the causal molecule of familial Parkinson’s disease. Although the characteristics of LRRK2 have gradually been revealed, its true physiological functions remain unknown. LRRK2 is highly expressed in immune cells such as B2 cells and macrophages, suggesting tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kubo, Makoto, Nagashima, Ryuichi, Kurihara, Mitsue, Kawakami, Fumitaka, Maekawa, Tatsunori, Eshima, Koji, Ohta, Etsuro, Kato, Hirotomo, Obata, Fumiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084871/ https://www.ncbi.nlm.nih.gov/pubmed/32164260 http://dx.doi.org/10.3390/ijms21051890

Ejemplares similares

LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
por: Kawakami, Fumitaka, et al.
Publicado: (2012)

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
por: Maekawa, Tatsunori, et al.
Publicado: (2012)

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
por: Maekawa, Tatsunori, et al.
Publicado: (2016)

Leucine-Rich Repeat Kinase 2 Is Associated With Activation of the Paraventricular Nucleus of the Hypothalamus and Stress-Related Gastrointestinal Dysmotility
por: Maekawa, Tatsunori, et al.
Publicado: (2019)

Histamine H(2)-Receptor Antagonists Improve Non-Steroidal Anti-Inflammatory Drug-Induced Intestinal Dysbiosis
por: Kawashima, Rei, et al.
Publicado: (2020)

Interleukin-13 Mediates Non-Steroidal Anti-Inflammatory-Drug-Induced Small Intestinal Mucosal Injury with Ulceration
por: Kawashima, Rei, et al.
Publicado: (2023)

The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
por: Kawakami, Fumitaka, et al.
Publicado: (2015)

Phosphorylated and Non-phosphorylated Leucine Rich Amelogenin Peptide Differentially Affect Ameloblast Mineralization
por: Le Norcy, Elvire, et al.
Publicado: (2018)

Glucocorticoid-Induced Leucine Zipper: Fine-Tuning of Dendritic Cells Function
por: Vétillard, Mathias, et al.
Publicado: (2018)

Bimodal Control of Dendritic and Axonal Growth by the Dual Leucine Zipper Kinase Pathway
por: Wang, Xin, et al.
Publicado: (2013)

Phosphorylation-Dependent Regulation of Ryanodine Receptors: A Novel Role for Leucine/Isoleucine Zippers
por: Marx, Steven O., et al.
Publicado: (2001)

Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey
por: Lane, MT, et al.
Publicado: (2017)

Protein Phosphorylation and Mineral Binding Affect the Secondary Structure of the Leucine-Rich Amelogenin Peptide
por: Yamazaki, Hajime, et al.
Publicado: (2017)

Induction of the glucocorticoid induced leucine zipper gene limits the efficacy of dendritic cell vaccines
por: Lebson, Lori, et al.
Publicado: (2011)

Leucine-Rich Repeat Transmembrane Proteins Instruct Discrete Dendrite Targeting in an Olfactory Map
por: Hong, Weizhe, et al.
Publicado: (2009)

Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif
por: Pungaliya, Pooja P., et al.
Publicado: (2010)

The transmembrane leucine-rich repeat protein DMA-1 promotes dendrite branching and growth in C. elegans
por: Liu, Oliver W., et al.
Publicado: (2011)

An NF-κB–Dependent Role for JunB in the Induction of Proinflammatory Cytokines in LPS-Activated Bone Marrow–Derived Dendritic Cells
por: Gomard, Tiphanie, et al.
Publicado: (2010)

NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells
por: Jones, Lauren G., et al.
Publicado: (2019)

NF-κB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65
por: Takeshima, Eriko, et al.
Publicado: (2009)

EGFR-dependent phosphorylation of leucine-rich repeat kinase LRRK1 is important for proper endosomal trafficking of EGFR
por: Ishikawa, Kouki, et al.
Publicado: (2012)

Mutations associated with retinopathies alter mitogen-activated protein kinase-induced phosphorylation of neural retina leucine-zipper
por: Swain, Prabodha, et al.
Publicado: (2007)

Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na(+)/K(+) ATPase Activity in Dendritic Cells
por: Hosseinzadeh, Zohreh, et al.
Publicado: (2017)

The Regulation of NF-κB Subunits by Phosphorylation
por: Christian, Frank, et al.
Publicado: (2016)

Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons
por: Heise, Christopher, et al.
Publicado: (2014)

Leucine-rich alpha-2 glycoprotein as a potential biomarker for large vessel vasculitides
por: Umezawa, Natsuka, et al.
Publicado: (2023)

Epoxymicheliolide, a novelguaiane-type sesquiterpene lactone, inhibits NF-κB/COX-2 signaling pathways by targeting leucine 281 and leucine 25 in IKKβ in renal cell carcinoma
por: Zhu, Jiabin, et al.
Publicado: (2018)

Super‐resolution structural analysis of dendritic spines using three‐dimensional structured illumination microscopy in cleared mouse brain slices
por: Sawada, Kazuaki, et al.
Publicado: (2018)

LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB
por: Kawaguchi, Yuki, et al.
Publicado: (2022)

Unexpected increase in the bone marrow toxicity of mitomycin C (MMC)
por: Yoshimoto, Masataka, et al.
Publicado: (2001)

Discrimination of the heterogeneity of bone marrow-derived dendritic cells
por: Wang, Jing, et al.
Publicado: (2017)

Retraction: NF-κB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65
por: Takeshima, Eriko, et al.
Publicado: (2011)

The role of Tsukushi (TSK), a small leucine-rich repeat proteoglycan, in bone growth
por: Yano, Kosei, et al.
Publicado: (2017)

Cloning and Expression of a Novel Leucine Dehydrogenase: Characterization and L-tert-Leucine Production
por: Luo, Wei, et al.
Publicado: (2020)

Differentiation of dendritic cells in cultures of rat bone marrow cells
Publicado: (1986)

Lactoferrin Induces Tolerogenic Bone Marrow-Derived Dendritic Cells
por: Park, Hui-Won, et al.
Publicado: (2020)

Giant Cell Arteritis Mimicking Polymyalgia Rheumatica: A Challenging Diagnosis
por: Ohta, Ryuichi, et al.
Publicado: (2022)

Autophagy in practice: stevia and leucine
por: Meijer, Alfred J.
Publicado: (2019)

Glucocorticoid-induced leucine zipper (GILZ)/NF-κB interaction: role of GILZ homo-dimerization and C-terminal domain
por: Marco, Barbara Di, et al.
Publicado: (2007)

Circadian Clock, Glucocorticoids and NF-κB Signaling in Neuroinflammation- Implicating Glucocorticoid Induced Leucine Zipper as a Molecular Link
por: Srinivasan, Mythily, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gr3el9lpacid8tphmj9fr7cr26