Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans

Duloxetine (DLX) is a potent drug investigated for the treatment of depression and urinary incontinence. DLX is extensively metabolized in the liver by two P450 isozymes, CYP2D6 and CYP1A2. Propolis (PPL) is one of the popular functional foods known to have effects on activities of CYPs, including C...

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Detalles Bibliográficos
Autores principales: Ngo, Thi Lien, Lee, Chung-Hee, Han, Nayoung, Back, Hyun-Moon, Rhee, Su-Jin, Noh, Keumhan, Yun, Hwi-Yeol, Kang, Wonku, Chae, Jung-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084906/
https://www.ncbi.nlm.nih.gov/pubmed/32182820
http://dx.doi.org/10.3390/ijms21051862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084906/
https://www.ncbi.nlm.nih.gov/pubmed/32182820
http://dx.doi.org/10.3390/ijms21051862

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