Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

BACKGROUND: Although phosphodiesterase-4 (PDE4) inhibitors have been shown to reduce COPD exacerbation rate, their biological mechanism of action is not completely elucidated at the molecular level. We aimed to characterise the whole genome gene expression profile of the inhaled PDE4-inhibitor CHF60...

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Detalles Bibliográficos
Autores principales: Govoni, Mirco, Bassi, Michele, Vezzoli, Stefano, Lucci, Germano, Emirova, Aida, Nandeuil, Marie Anna, Petruzzelli, Stefano, Jellema, Gera L., Afolabi, Ebenezer K., Colgan, Brendan, Leaker, Brian, Kornmann, Oliver, Beeh, Kai Michael, Watz, Henrik, Singh, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085203/
https://www.ncbi.nlm.nih.gov/pubmed/32197620
http://dx.doi.org/10.1186/s12931-020-1329-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085203/
https://www.ncbi.nlm.nih.gov/pubmed/32197620
http://dx.doi.org/10.1186/s12931-020-1329-y

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