Targeting MEK5 impairs non-homologous end-joining repair and sensitizes prostate cancer to DNA damaging agents

Radiotherapy is commonly used to treat a variety of solid human tumors, including localized prostate cancer. However, treatment failure often ensues due to tumor intrinsic or acquired radioresistance. Here we find that the MEK5/ERK5 signaling pathway is associated with resistance to genotoxic stress...

Descripción completa

Detalles Bibliográficos
Autores principales: Broustas, Constantinos G., Duval, Axel J., Chaudhary, Kunal R., Friedman, Richard A., Virk, Renu K., Lieberman, Howard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085449/
https://www.ncbi.nlm.nih.gov/pubmed/31980741
http://dx.doi.org/10.1038/s41388-020-1163-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085449/
https://www.ncbi.nlm.nih.gov/pubmed/31980741
http://dx.doi.org/10.1038/s41388-020-1163-1

Ejemplares similares