The Multifunctional Protein PACS-1 is Required for HDAC2 and HDAC3 Dependent Chromatin Maturation and Genomic Stability

Phosphofurin acidic cluster sorting protein-1 (PACS-1) is a multifunctional membrane traffic regulator that plays important roles in organ homeostasis and disease. In this study, we elucidate a novel nuclear function for PACS-1 in maintaining chromosomal integrity. PACS-1 progressively accumulates i...

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Detalles Bibliográficos
Autores principales: Mani, Chinnadurai, Tripathi, Kaushlendra, Luan, Shan, Clark, David W., Andrews, Joel F., Vindigni, Alessandro, Thomas, Gary, Palle, Komaraiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085454/
https://www.ncbi.nlm.nih.gov/pubmed/31988453
http://dx.doi.org/10.1038/s41388-020-1167-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085454/
https://www.ncbi.nlm.nih.gov/pubmed/31988453
http://dx.doi.org/10.1038/s41388-020-1167-x

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