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The Molecular Basis of the Interaction of Cyclophilin A with α‐Synuclein

Peptidylprolyl isomerases (PPIases) catalyze cis/trans isomerization of prolines. The PPIase CypA colocalizes with the Parkinson's disease (PD)‐associated protein α‐synuclein in cells and interacts with α‐synuclein oligomers. Herein, we describe atomic insights into the molecular details of the...

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Detalles Bibliográficos
Autores principales: Favretto, Filippo, Baker, Jeremy D., Strohäker, Timo, Andreas, Loren B., Blair, Laura J., Becker, Stefan, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085457/
https://www.ncbi.nlm.nih.gov/pubmed/31830361
http://dx.doi.org/10.1002/anie.201914878