Copy Number Amplification of DNA Damage Repair Pathways Potentiates Therapeutic Resistance in Cancer

Rationale: Loss of DNA damage repair (DDR) in the tumor is an established hallmark of sensitivity to DNA damaging agents such as chemotherapy. However, there has been scant investigation into gain-of-function alterations of DDR genes in cancer. This study aims to investigate to what extent copy numb...

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Detalles Bibliográficos
Autores principales: Wu, Zhiyuan, Li, Sihan, Tang, Xuemei, Wang, Yue, Guo, Weiwei, Cao, Guojun, Chen, Kun, Zhang, Min, Guan, Ming, Yang, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086350/
https://www.ncbi.nlm.nih.gov/pubmed/32226530
http://dx.doi.org/10.7150/thno.39341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086350/
https://www.ncbi.nlm.nih.gov/pubmed/32226530
http://dx.doi.org/10.7150/thno.39341

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