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Temperature-sensitive mutants of mouse hepatitis virus type 3 (MHV-3): isolation, biochemical and genetic characterization

Mouse hepatitis virus 3 (MHV-3) is highly hepatotropic in sensitive mice. Temperature-sensitive mutants (ts mutants) induced by N-methyl-N′-nitrosoguanidine and 5-fluorouracil were isolated. Twelve mutants which were able to induce the formation of syncytia at 33°C but not at the restrictive tempera...

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Detalles Bibliográficos
Autores principales: Martin, J. -P., Koehren, Françoise, Rannou, J. -J., Kirn, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086851/
https://www.ncbi.nlm.nih.gov/pubmed/2840870
http://dx.doi.org/10.1007/BF01487679