Silica nanomaterials induce organ injuries by Ca(2+)-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

BACKGROUND: The growing use of silica nanoparticles (SiNPs) in many fields raises human toxicity concerns. We studied the toxicity of SiNP-20 (particle diameter 20 nm) and SiNP-100 (100 nm) and the underlying mechanisms with a focus on the endothelium both in vitro and in vivo. METHODS: The study wa...

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Detalles Bibliográficos
Autores principales: Wang, De-Ping, Wang, Zhao-Jun, Zhao, Rong, Lin, Cai-Xia, Sun, Qian-Yu, Yan, Cai-Ping, Zhou, Xin, Cao, Ji-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087393/
https://www.ncbi.nlm.nih.gov/pubmed/32293491
http://dx.doi.org/10.1186/s12989-020-00340-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087393/
https://www.ncbi.nlm.nih.gov/pubmed/32293491
http://dx.doi.org/10.1186/s12989-020-00340-8

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