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Silica nanomaterials induce organ injuries by Ca(2+)-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation
BACKGROUND: The growing use of silica nanoparticles (SiNPs) in many fields raises human toxicity concerns. We studied the toxicity of SiNP-20 (particle diameter 20 nm) and SiNP-100 (100 nm) and the underlying mechanisms with a focus on the endothelium both in vitro and in vivo. METHODS: The study wa...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087393/ https://www.ncbi.nlm.nih.gov/pubmed/32293491 http://dx.doi.org/10.1186/s12989-020-00340-8 |