Sexually Divergent Mortality and Partial Phenotypic Rescue After Gene Therapy in a Mouse Model of Dravet Syndrome

Dravet syndrome (DS) is a neurodevelopmental genetic disorder caused by mutations in the SCN1A gene encoding the α subunit of the NaV1.1 voltage-gated sodium channel that controls neuronal action potential firing. The high density of this mutated channel in GABAergic interneurons results in impaired...

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Detalles Bibliográficos
Autores principales: Niibori, Yosuke, Lee, Shiron J., Minassian, Berge A., Hampson, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087406/
https://www.ncbi.nlm.nih.gov/pubmed/31830809
http://dx.doi.org/10.1089/hum.2019.225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087406/
https://www.ncbi.nlm.nih.gov/pubmed/31830809
http://dx.doi.org/10.1089/hum.2019.225

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