Synthesis, antiviral, cytotoxic and cytostatic evaluation of N(1)-(phosphonoalkyl)uracil derivatives

ABSTRACT: A series of N (1)-(phosphonoalkyl)uracils was prepared in a two-step reaction sequence from ω-aminoalkylphosphonates and (E)-3-ethoxyacryloyl isocyanate followed by the uracil ring closure. Under standard conditions (NCS; NBS; I(2)/CAN) all N (1)-(phosphonoalkyl)uracils were transformed in...

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Detalles Bibliográficos
Autores principales: Rygielska-Tokarska, Dorota, Andrei, Graciela, Schols, Dominique, Snoeck, Robert, Głowacka, Iwona E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087680/
https://www.ncbi.nlm.nih.gov/pubmed/32214481
http://dx.doi.org/10.1007/s00706-016-1701-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087680/
https://www.ncbi.nlm.nih.gov/pubmed/32214481
http://dx.doi.org/10.1007/s00706-016-1701-2

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