Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches

Essential for viral replication and highly conserved among poxviridae, the vaccinia virus I7L ubiquitin-like proteinase (ULP) is an attractive target for development of smallpox antiviral drugs. At the same time, the I7L proteinase exemplifies several interesting challenges from the rational drug de...

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Detalles Bibliográficos
Autores principales: Katritch, Vsevolod, Byrd, Chelsea M., Tseitin, Vladimir, Dai, Dongcheng, Raush, Eugene, Totrov, Maxim, Abagyan, Ruben, Jordan, Robert, Hruby, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087885/
https://www.ncbi.nlm.nih.gov/pubmed/17960327
http://dx.doi.org/10.1007/s10822-007-9138-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087885/
https://www.ncbi.nlm.nih.gov/pubmed/17960327
http://dx.doi.org/10.1007/s10822-007-9138-7

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