Mutations in the spike gene of porcine epidemic diarrhea virus associated with growth adaptation in vitro and attenuation of virulence in vivo

Previously, we have reported that a serial passage of 83P-5 strain of porcine epidemic diarrhea virus (PEDV) in Vero cells resulted in a growth adaptation of the virus in cultured cells at the 22nd passage. In this study, we further maintained the 83P-5 in Vero cells up to the 100th passage and anal...

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Detalles Bibliográficos
Autores principales: Sato, Tetsuo, Takeyama, Natsumi, Katsumata, Atsushi, Tuchiya, Kotaro, Kodama, Toshiaki, Kusanagi, Ko-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088782/
https://www.ncbi.nlm.nih.gov/pubmed/21559974
http://dx.doi.org/10.1007/s11262-011-0617-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088782/
https://www.ncbi.nlm.nih.gov/pubmed/21559974
http://dx.doi.org/10.1007/s11262-011-0617-5

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