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Improved synthesis of rupintrivir

An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, fo...

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Detalles Bibliográficos
Autores principales: Lin, DaiZong, Qian, WangKe, Hilgenfeld, Rolf, Jiang, HuaLiang, Chen, KaiXian, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Science China Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088791/
https://www.ncbi.nlm.nih.gov/pubmed/32215000
http://dx.doi.org/10.1007/s11426-011-4478-5