Improved synthesis of rupintrivir

An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, fo...

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Detalles Bibliográficos
Autores principales: Lin, DaiZong, Qian, WangKe, Hilgenfeld, Rolf, Jiang, HuaLiang, Chen, KaiXian, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Science China Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088791/
https://www.ncbi.nlm.nih.gov/pubmed/32215000
http://dx.doi.org/10.1007/s11426-011-4478-5
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author Lin, DaiZong
Qian, WangKe
Hilgenfeld, Rolf
Jiang, HuaLiang
Chen, KaiXian
Liu, Hong
author_facet Lin, DaiZong
Qian, WangKe
Hilgenfeld, Rolf
Jiang, HuaLiang
Chen, KaiXian
Liu, Hong
author_sort Lin, DaiZong
collection PubMed
description An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
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spelling pubmed-70887912020-03-23 Improved synthesis of rupintrivir Lin, DaiZong Qian, WangKe Hilgenfeld, Rolf Jiang, HuaLiang Chen, KaiXian Liu, Hong Sci China Chem Articles An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps. SP Science China Press 2012-01-04 2012 /pmc/articles/PMC7088791/ /pubmed/32215000 http://dx.doi.org/10.1007/s11426-011-4478-5 Text en © Science China Press and Springer-Verlag Berlin Heidelberg 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Articles
Lin, DaiZong
Qian, WangKe
Hilgenfeld, Rolf
Jiang, HuaLiang
Chen, KaiXian
Liu, Hong
Improved synthesis of rupintrivir
title Improved synthesis of rupintrivir
title_full Improved synthesis of rupintrivir
title_fullStr Improved synthesis of rupintrivir
title_full_unstemmed Improved synthesis of rupintrivir
title_short Improved synthesis of rupintrivir
title_sort improved synthesis of rupintrivir
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088791/
https://www.ncbi.nlm.nih.gov/pubmed/32215000
http://dx.doi.org/10.1007/s11426-011-4478-5
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AT jianghualiang improvedsynthesisofrupintrivir
AT chenkaixian improvedsynthesisofrupintrivir
AT liuhong improvedsynthesisofrupintrivir

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