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Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors
Aminopeptidase N (APN) inhibitors have been reported to be effective in treating of life threatening diseases including cancer. Validated ligand- and structure-based pharmacophore mapping approaches were combined with Bayesian modeling and recursive partitioning to identify structural and physicoche...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089330/ https://www.ncbi.nlm.nih.gov/pubmed/23341006 http://dx.doi.org/10.1007/s11030-013-9422-5 |