Cargando…

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

BACKGROUND: Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic instruments for lipoprotein lipid traits implemented through multivariable Mend...

Descripción completa

Detalles Bibliográficos
Autores principales:	Richardson, Tom G., Sanderson, Eleanor, Palmer, Tom M., Ala-Korpela, Mika, Ference, Brian A., Davey Smith, George, Holmes, Michael V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089422/ https://www.ncbi.nlm.nih.gov/pubmed/32203549 http://dx.doi.org/10.1371/journal.pmed.1003062

Ejemplares similares

Effects of general and central adiposity on circulating lipoprotein, lipid, and metabolite levels in UK Biobank: A multivariable Mendelian randomization study
por: Bell, Joshua A., et al.
Publicado: (2022)

Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a mendelian randomisation analysis using outcomes in first-degree relatives
por: Richardson, Tom G, et al.
Publicado: (2021)

The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses
por: Rasheed, Humaira, et al.
Publicado: (2021)

A phenome-wide bidirectional Mendelian randomization analysis of atrial fibrillation
por: Wang, Qin, et al.
Publicado: (2022)

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease
por: Zuber, Verena, et al.
Publicado: (2020)

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization
por: Sanderson, Eleanor, et al.
Publicado: (2022)

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis
por: Richardson, Tom G, et al.
Publicado: (2021)

The relationship between lipoprotein A and other lipids with prostate cancer risk: A multivariable Mendelian randomisation study
por: Ioannidou, Anna, et al.
Publicado: (2022)

Circulating Lipoprotein Lipids, Apolipoproteins and Ischemic Stroke
por: Yuan, Shuai, et al.
Publicado: (2020)

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study
por: Richardson, Tom G, et al.
Publicado: (2020)

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
por: Richardson, Tom G., et al.
Publicado: (2022)

The use of negative control outcomes in Mendelian randomization to detect potential population stratification
por: Sanderson, Eleanor, et al.
Publicado: (2021)

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
por: Sanderson, Eleanor, et al.
Publicado: (2019)

Corrigendum to: An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
por: Sanderson, Eleanor, et al.
Publicado: (2020)

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health
por: Davies, Neil Martin, et al.
Publicado: (2019)

The mediating role of mammographic density in the protective effect of early-life adiposity on breast cancer risk: a multivariable Mendelian randomization study
por: Vabistsevits, Marina, et al.
Publicado: (2023)

Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study
por: Norris, Tom, et al.
Publicado: (2023)

Testing and correcting for weak and pleiotropic instruments in two‐sample multivariable Mendelian randomization
por: Sanderson, Eleanor, et al.
Publicado: (2021)

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour
por: Sanderson, Eleanor, et al.
Publicado: (2019)

Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis
por: Saleheen, Danish, et al.
Publicado: (2017)

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization
por: Vabistsevits, Marina, et al.
Publicado: (2022)

Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization
por: Hu, Gaofu, et al.
Publicado: (2023)

Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study
por: Tan, Vanessa Y., et al.
Publicado: (2021)

A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer
por: Gormley, Mark, et al.
Publicado: (2020)

Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study
por: Zhao, Sizheng Steven, et al.
Publicado: (2022)

Education and coronary heart disease: mendelian randomisation study
por: Tillmann, Taavi, et al.
Publicado: (2017)

The Association between Circulating Lipids and Female Infertility Risk: A Univariable and Multivariable Mendelian Randomization Analysis
por: Zhu, Xiaoqi, et al.
Publicado: (2023)

Mendelian randomisation for mediation analysis: current methods and challenges for implementation
por: Carter, Alice R., et al.
Publicado: (2021)

Reappraising the role of instrumental inequalities for mendelian randomization studies in the mega Biobank era
por: Sanderson, Eleanor, et al.
Publicado: (2023)

Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases
por: Sobczyk, Maria K, et al.
Publicado: (2023)

Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke
por: Holmes, Michael V., et al.
Publicado: (2018)

Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization
por: Richardson, Tom G, et al.
Publicado: (2023)

Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study
por: Fang, Si, et al.
Publicado: (2023)

Association between Lipids, Apolipoproteins and Telomere Length: A Mendelian Randomization Study
por: Zhu, Gehua, et al.
Publicado: (2023)

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study
por: Anderson, Emma L, et al.
Publicado: (2020)

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions
por: Burgess, Stephen, et al.
Publicado: (2014)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
por: Cho, Yoonsu, et al.
Publicado: (2020)

Integrating the Biology of Cardiovascular Disease into the Epidemiology of Economic Decision Modelling via Mendelian Randomisation
por: Ademi, Zanfina, et al.
Publicado: (2022)

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index
por: Hartley, April, et al.
Publicado: (2021)

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
por: Davies, Neil M, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3e7oepn5jnvoapimnl8kue7iii