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In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
Epilepsy is a major health burden, calling for new mechanistic insights and therapies. CRISPR-mediated gene editing shows promise to cure genetic pathologies, although hitherto it has mostly been applied ex vivo. Its translational potential for treating non-genetic pathologies is still unexplored. F...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089667/ https://www.ncbi.nlm.nih.gov/pubmed/32129831 http://dx.doi.org/10.1093/brain/awaa045 |