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The guide sRNA sequence determines the activity level of box C/D RNPs

2’-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP complex in an RNA-guided manner. Despite the conservation of the methylation sites, the abundance of site-specific modifications shows variability across species and tissues, suggesting that rRNA met...

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Detalles Bibliográficos
Autores principales: Graziadei, Andrea, Gabel, Frank, Kirkpatrick, John, Carlomagno, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089733/
https://www.ncbi.nlm.nih.gov/pubmed/32202498
http://dx.doi.org/10.7554/eLife.50027