Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

Topoisomerase II (TOP2) relieves topological stress in DNA by introducing double-strand breaks (DSBs) via a transient, covalently linked TOP2 DNA-protein intermediate, termed TOP2 cleavage complex (TOP2cc). TOP2ccs are normally rapidly reversible, but can be stabilized by TOP2 poisons, such as the c...

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Detalles Bibliográficos
Autores principales: Sciascia, Nicholas, Wu, Wei, Zong, Dali, Sun, Yilun, Wong, Nancy, John, Sam, Wangsa, Darawalee, Ried, Thomas, Bunting, Samuel F, Pommier, Yves, Nussenzweig, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089766/
https://www.ncbi.nlm.nih.gov/pubmed/32057297
http://dx.doi.org/10.7554/eLife.53447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089766/
https://www.ncbi.nlm.nih.gov/pubmed/32057297
http://dx.doi.org/10.7554/eLife.53447

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