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Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells
Aberrant neuroendocrine signaling is frequent yet poorly understood feature of prostate cancers. Membrane metalloendopeptidase (MME) is responsible for the catalytic inactivation of neuropeptide substrates, and is downregulated in nearly 50% of prostate cancers. However its role in prostate carcinog...
Autores principales: | Cheng, Chieh-Yang, Zhou, Zongxiang, Stone, Meredith, Lu, Bao, Flesken-Nikitin, Andrea, Nanus, David M., Nikitin, Alexander Yu. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090072/ https://www.ncbi.nlm.nih.gov/pubmed/32205838 http://dx.doi.org/10.1038/s41389-020-0222-3 |
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