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Development of encoded Broccoli RNA aptamers for live cell imaging of alphavirus genomic and subgenomic RNAs

Sindbis virus (SINV) can infect neurons and cause encephalomyelitis in mice. Nonstructural proteins are translated from genomic RNA and structural proteins from subgenomic RNA. While visualization of viral proteins in living cells is well developed, imaging of viral RNAs has been challenging. RNA ap...

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Detalles Bibliográficos
Autores principales: Nilaratanakul, Voraphoj, Hauer, Debra A., Griffin, Diane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090087/
https://www.ncbi.nlm.nih.gov/pubmed/32251299
http://dx.doi.org/10.1038/s41598-020-61573-3