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p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency

PURPOSE: p62/Sequestosome 1 (p62) is a stress-induced protein that is involved in several different intracellular pathways, including regulation of aspects of protein degradation. p62 levels are elevated in several types of cataracts. We investigated whether levels of p62 and its phosphorylation wer...

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Detalles Bibliográficos
Autores principales: Jara, Oscar, Mysliwiec, Hubert, Minogue, Peter J., Berthoud, Viviana M., Beyer, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090271/
https://www.ncbi.nlm.nih.gov/pubmed/32214786