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Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV)
Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it wa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pharmaceutical Society of Korea
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090976/ https://www.ncbi.nlm.nih.gov/pubmed/22297745 http://dx.doi.org/10.1007/s12272-012-0108-9 |
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author | Park, Hye Ri Yoon, Hyunjun Kim, Mi Kyoung Lee, Sung Dae Chong, Youhoon |
author_facet | Park, Hye Ri Yoon, Hyunjun Kim, Mi Kyoung Lee, Sung Dae Chong, Youhoon |
author_sort | Park, Hye Ri |
collection | PubMed |
description | Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV. |
format | Online Article Text |
id | pubmed-7090976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Pharmaceutical Society of Korea |
record_format | MEDLINE/PubMed |
spelling | pubmed-70909762020-03-24 Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) Park, Hye Ri Yoon, Hyunjun Kim, Mi Kyoung Lee, Sung Dae Chong, Youhoon Arch Pharm Res Research Article Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV. Pharmaceutical Society of Korea 2012-02-02 2012 /pmc/articles/PMC7090976/ /pubmed/22297745 http://dx.doi.org/10.1007/s12272-012-0108-9 Text en © The Pharmaceutical Society of Korea and Springer Netherlands 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Research Article Park, Hye Ri Yoon, Hyunjun Kim, Mi Kyoung Lee, Sung Dae Chong, Youhoon Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) |
title | Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) |
title_full | Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) |
title_fullStr | Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) |
title_full_unstemmed | Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) |
title_short | Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) |
title_sort | synthesis and antiviral evaluation of 7-o-arylmethylquercetin derivatives against sars-associated coronavirus (scv) and hepatitis c virus (hcv) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090976/ https://www.ncbi.nlm.nih.gov/pubmed/22297745 http://dx.doi.org/10.1007/s12272-012-0108-9 |
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