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Polycations increase the efficiency of adenovirus-mediated gene transfer to epithelial and endothelial cells in vitro

Recombinant adenoviruses are being developed for gene therapy for cystic fibrosis and other lung diseases, and for prevention and treatment of vascular thrombosis. A major limitation to the clinical utility of adenoviruses is the low efficiency of gene transfer achieved in vivo. In addition, little...

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Detalles Bibliográficos
Autores principales: Arcasoy, SM, Latoche, JD, Gondor, M, Pitt, BR, Pilewski, JM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 1997
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091802/
https://www.ncbi.nlm.nih.gov/pubmed/9068793
http://dx.doi.org/10.1038/sj.gt.3300349