Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats

Extended-release buprenorphine is an effective analgesic in laboratory animals, and its safety has been established in mice but not in rats. The authors used a target animal safety trial to evaluate the safety of extended-release buprenorphine in rats. Fischer 344 rats received post-surgical subcuta...

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Detalles Bibliográficos
Autores principales: Cowan, Alan, Sarabia-Estrada, Rachel, Wilkerson, Gina, McKnight, Patrick, Guarnieri, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092016/
https://www.ncbi.nlm.nih.gov/pubmed/26684956
http://dx.doi.org/10.1038/laban.745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092016/
https://www.ncbi.nlm.nih.gov/pubmed/26684956
http://dx.doi.org/10.1038/laban.745

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