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Lack of adverse effects during a target animal safety trial of extended-release buprenorphine in Fischer 344 rats
Extended-release buprenorphine is an effective analgesic in laboratory animals, and its safety has been established in mice but not in rats. The authors used a target animal safety trial to evaluate the safety of extended-release buprenorphine in rats. Fischer 344 rats received post-surgical subcuta...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092016/ https://www.ncbi.nlm.nih.gov/pubmed/26684956 http://dx.doi.org/10.1038/laban.745 |