Cargando…

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells

BACKGROUND: DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local transcriptional potential. Here, we present RT profil...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Peiyao A., Sasaki, Takayo, Gilbert, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092589/
https://www.ncbi.nlm.nih.gov/pubmed/32209126
http://dx.doi.org/10.1186/s13059-020-01983-8