Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

The papain-like protease of severe acute respiratory syndrome coronavirus (PLpro) (EC 3.4.22.46) is essential for the viral life cycle and therefore represents an important antiviral target. We have identified 6MP and 6TG as reversible and slow-binding inhibitors of SARS-CoV PLpro, which is the firs...

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Detalles Bibliográficos
Autores principales: Chou, Chi-Yuan, Chien, Chia-Hui, Han, Yu-San, Prebanda, Mojca Trstenjak, Hsieh, Hsing-Pang, Turk, Boris, Chang, Gu-Gang, Chen, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092826/
https://www.ncbi.nlm.nih.gov/pubmed/18313035
http://dx.doi.org/10.1016/j.bcp.2008.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092826/
https://www.ncbi.nlm.nih.gov/pubmed/18313035
http://dx.doi.org/10.1016/j.bcp.2008.01.005

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