A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity

The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has two major functions: interacting with the receptor to mediate virus entry and inducing protective immunity. Coincidently, the receptor-binding domain (RBD, residues 318–510) of SAR-CoV S protein is a major antigeni...

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Detalles Bibliográficos
Autores principales: He, Yuxian, Li, Jingjing, Jiang, Shibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092835/
https://www.ncbi.nlm.nih.gov/pubmed/16615996
http://dx.doi.org/10.1016/j.bbrc.2006.03.139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092835/
https://www.ncbi.nlm.nih.gov/pubmed/16615996
http://dx.doi.org/10.1016/j.bbrc.2006.03.139

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